![]() There were no significant differences between the study regimens by the outcome criteria evaluated. Septic-related mortality occurred in 18 (19%) patients, and two (2%) patients had unrelated deaths. Twenty-five patients (27%) subsequently developed unsatisfactory courses, but 48 (52%) patients remained well through the 30-day period. Initial satisfactory clinical responses were obtained in 59 (63%) patients. Study antibiotics were changed for bacteriologic reasons in 11 patients taking clindamycin-gentamicin and 12 patients taking chloramphenicol-gentamicin (25% of the total), and two patients in the clindamycin-gentamicin group had a minor adverse reaction. The duration of antibiotic treatment averaged 8½ days, and the average length of postoperative hospitalization was 29 days. Malnutrition, age over 65 years, shock, alcoholism, gastrointestinal tract bleeding, steroid administration, diabetes, obesity, and organ malfunction were present with equal frequencies in each group. including reinfection or relapse, may require the addition of an injectable aminoglycoside. Recommendations on dosing and duration of aminoglycoside therapy vary we detail the laboratory and clinical evidence base for the treatment regimens advised. The study compared clindamycin-gentamicin and chloramphenicol-gentamicin for treatment of carefully stratified patient groups. Significant synergy was reported against all MAC isolates. Aminoglycosides are often used in combination with glycopeptides and -lactams for the treatment of bacterial endocarditis caused by -haemolytic streptococci, staphylococci and enterococci. Standard EIDA should NOT be utilized in patients with Infective Endocarditis due to gram-positive organisms (synergy dosing). A randomized, prospective trial was conducted of 93 patients with operatively confirmed intra-abdominal sepsis. dosing rather, it denotes the use of empiric 5 mg/kg doses (gentamicin and tobramycin) or 15 mg/kg doses (amikacin) in an attempt to maximize peak concentration while also approximating undetectable troughs.
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